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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT1
All Species:
20.91
Human Site:
Y642
Identified Species:
38.33
UniProt:
Q96EB6
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96EB6
NP_001135970.1
747
81681
Y642
R
R
L
D
G
N
Q
Y
L
F
L
P
P
N
R
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001087854
741
80936
Y636
K
R
L
D
G
N
Q
Y
L
F
L
P
P
N
R
Dog
Lupus familis
XP_546130
745
81496
Y640
K
R
L
D
G
N
Q
Y
L
F
L
P
P
N
R
Cat
Felis silvestris
Mouse
Mus musculus
Q923E4
737
80353
Y632
K
R
L
E
G
N
Q
Y
L
F
V
P
P
N
R
Rat
Rattus norvegicus
Q5RJQ4
350
39301
E251
P
R
L
L
I
N
K
E
K
T
G
Q
T
D
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508324
480
51688
I381
F
L
P
P
N
R
Y
I
F
H
G
A
E
V
Y
Chicken
Gallus gallus
NP_001004767
756
82614
Y654
K
R
L
D
G
T
Q
Y
L
F
L
P
P
N
R
Frog
Xenopus laevis
NP_001091195
710
78684
Q604
E
N
K
Y
T
K
E
Q
I
S
K
R
L
D
S
Zebra Danio
Brachydanio rerio
Q7ZVK3
379
42296
R280
R
V
S
N
R
C
P
R
L
L
I
N
M
E
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477351
823
91818
Y678
R
L
Q
P
G
T
F
Y
S
H
T
N
N
Y
S
Honey Bee
Apis mellifera
XP_395386
868
98678
Y720
E
R
L
P
E
N
S
Y
Y
Q
L
A
P
G
K
Nematode Worm
Caenorhab. elegans
Q21921
607
68747
F508
I
S
A
H
Q
T
V
F
P
G
A
E
C
S
F
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53685
503
57684
E404
T
I
R
K
D
I
L
E
C
D
L
L
I
C
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
93.3
91.4
N.A.
85.1
23.4
N.A.
49.7
68.1
57.9
22.2
N.A.
37.2
39.9
31.3
N.A.
Protein Similarity:
100
N.A.
95.5
94.3
N.A.
90
33.3
N.A.
54.7
75.4
69.3
35
N.A.
52.2
55.9
47.5
N.A.
P-Site Identity:
100
N.A.
93.3
93.3
N.A.
80
20
N.A.
0
86.6
0
13.3
N.A.
20
40
0
N.A.
P-Site Similarity:
100
N.A.
100
100
N.A.
100
33.3
N.A.
0
93.3
20
33.3
N.A.
20
46.6
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
22.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
35.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
0
0
0
0
8
16
0
0
0
% A
% Cys:
0
0
0
0
0
8
0
0
8
0
0
0
8
8
0
% C
% Asp:
0
0
0
31
8
0
0
0
0
8
0
0
0
16
0
% D
% Glu:
16
0
0
8
8
0
8
16
0
0
0
8
8
8
0
% E
% Phe:
8
0
0
0
0
0
8
8
8
39
0
0
0
0
8
% F
% Gly:
0
0
0
0
47
0
0
0
0
8
16
0
0
8
0
% G
% His:
0
0
0
8
0
0
0
0
0
16
0
0
0
0
0
% H
% Ile:
8
8
0
0
8
8
0
8
8
0
8
0
8
0
8
% I
% Lys:
31
0
8
8
0
8
8
0
8
0
8
0
0
0
16
% K
% Leu:
0
16
54
8
0
0
8
0
47
8
47
8
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% M
% Asn:
0
8
0
8
8
47
0
0
0
0
0
16
8
39
0
% N
% Pro:
8
0
8
24
0
0
8
0
8
0
0
39
47
0
8
% P
% Gln:
0
0
8
0
8
0
39
8
0
8
0
8
0
0
0
% Q
% Arg:
24
54
8
0
8
8
0
8
0
0
0
8
0
0
39
% R
% Ser:
0
8
8
0
0
0
8
0
8
8
0
0
0
8
16
% S
% Thr:
8
0
0
0
8
24
0
0
0
8
8
0
8
0
0
% T
% Val:
0
8
0
0
0
0
8
0
0
0
8
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
8
54
8
0
0
0
0
8
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _